Life Sciences R&D :: Data Curation Services
Life Sciences R & D Solutions
Software Development
         Cheminformatics
         Bioinformatics
Scientific Software Testing
Scientific Data Curation
Consulting
 

Modern Biology, chemistry techniques and practices generate outsized amount of data and huge number of chemical compounds. As a consequence, one of the biggest challenges is to tag all of the available information so they can analyze and generate knowledge from it.

Siri has identified the importance of data management and offers following curation and database services

Siri helps you in curation of Chemical, Biological, Pre-Clinical, Clinical and ADME/Toxicology databases. We use multiple source including, patents, journals and other sources of literature. These Databases can add value to the ongoing target identification, lead identification and lead optimization in your drug discovery programs.

Our data curation services are focused to create reusable knowledgebase. The following table indicates the key parameters that we identified with respect to chemical, biological, pharmacology and bibliographic databases:

 Key Parameters
Chemistry 2D structure, molecular weight, molecular formula, IUPAC name, SMILE notation etc,
Biology Therapeutic indication, target information, assay, and activity information
Pharmacology ADMET parameters
Bibliography Patent/Article number, Approval/expiry dates, Author names etc.,
Annotations and ontology  

We have identified some of the important databases that we can curate:

  • Small molecule databases with biological, pharmacological activities
  • Known drugs database
  • Reaction databases
  • Toxicology database
  • Clinical, pre-clinical database
  • Gene/protein/mutant/pathway centric database with development of controlled vocabularies, allied interfaces and validating them against GO, TO ontologies
  • Protein-protein interactions, QTLs, gene/protein families, biomarkers, expression/toxicology profiling and synteny databases to understand the conservation across different systems
  • Metabolic pathway databases - support with microarray-analyzed expression profiling, custom tool development for drawing pathways and link them to various sources
  • Custom newsletters subscription – Screen, compile and publish custom alerts with latest published information on important candidate genes and other client specific requirements

    Databases can also be customized as per your requirements. We have identified some of your critical needs and recommend using the following database services:

    Database
    Usage
    • All compounds studied against a class of protein
    • Compounds active against a particular Target or set of Targets.
    • Compounds with ADMET data
    • Compounds with only pre-clinical and clinical data
    • Appending data for a given compound / set of compounds from various sources into a unique structure library database
    • FDA approved Drug database

     

    • Identify scaffolds associated with a biological activity
    • Categorize large structure data sets using the chemical diversity
    • Identify structural fragments responsible for activity/toxicity
    • Compare compounds with toxicity and known drug databases
    • Search & analyze combinatorial libraries using scaffolds
    • Identify scaffolds and subject the set of structures for R-Group deconvolution studies
    • Recognize the activity, or selectivity, relationship of structure fragments and R-Group analysis
    • Generate pharmacophores from set of active structures against a target or class of targets.
    • Identify compounds for screening
   

DataBases
Oracle 9i
MS SQL 2000
DB2
MySQL


Platforms
MS Windows
Linux/UNIX
Sun Solaris
HP UX
IBM AIX
SGI

 

For more information on our services, contact us today!