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Biopharmaceutical
companies constantly face
technology and manpower challenges.
One, drug discovery involves
usage of expensive analytical
tools and technologies that
are difficult to acquire.
Two, it is not uncommon to
find shortage of skills to
work on these technologies.
Siri
has both technology and highly
qualified chemists and biologists
to address these challenges.
We provide offshore services,
for instance, to develop new
lead molecules for desired
target using our in-house
technologies. We can also
provide on-site services if
you have tools that are inadequately
equipped with manpower. Even
as we deliver these services,
we ensure that Intellectual
Properties (IPs) of our clients
are protected. Siri has state-of-art
facility and also stringent
processes to maintain confidentiality
across projects
Structure-based
Drug Design
Siri
can provide structure-based
drug design services if
the 3D structure of the
binding site on a target
(enzyme/receptor) is known.
We specialize in Docking
and de Novo techniques to
design ligands that are
likely to interact with
the binding site of a target
and find out the optimum
interaction.
Analog-based
Drug Design
In many instances where
the 3D structure of the
binding site is unknown,
Siri can provide pharmacophore
modeling and QSAR (Quantitative
Structure Activity Relationships)
based drug design services.
We can develop 3D interaction
map based on known active
analogs for the intended
target. By applying appropriate
technology, we can develop
statistical models on physico-chemical
properties and design ligands
for target.
Virtual
Ligand Screening
We can help you with in-silico
screening of large databases
of chemical compounds using
Docking or Pharmacophore
models, depending on the
availability of 3D structure
for the binding site. Siri’s
offshore and on-site services
can be exploited to identify
leads faster and reduce
costs.
Data
Analysis
Siri provides data management
and analysis services, including
molecular diversity/clustering
analysis, database characterization,
analog discovery and directed
structure selection for
binding assays/toxicity
etc. Our data analysis services
are geared towards saving
time in virtual/experimental
screening of compounds
ADMET
Modeling
We can develop models to
predict of ADME and Tox
properties that are useful
for medicinal chemists.
Our ADMET Modeling services
are focused to minimize
attrition of candidates
at an advanced level of
drug discovery/development
Bioinformatics
Genomics
and proteomics data requires
intensive analysis and
validation. A large volume
of data comes in and out
of innumerous laboratory
experiments. Siri offers
consulting services in
data analysis of the following:
Genomics/Proteomics
Data Analysis
We provide sequence
analysis, gene identification,
boundary validation and function
prediction services. These
services include
-
Sequence
analysis of any given
data by using various
publicly available bioinformatics
tools like Blast, ClustalW,
Pfam, SW, PSI Blast
etc.,
-
Gene
identification to validate
the correct start and
stop of the coding sequence
in the correct frame for
validating the right candidate
genes before proceeding
for transformation studies.
-
Screening the identified
candidates for various
parameters such as similarity
to any known allergen/toxin
by checking them against
required sources to validate
the genes for further
selection.
-
Compiling information
on previous reports of
transgenic studies on
any chosen gene to give
a comprehensive idea on
the expected behavioral
patterns in the transgenic
in different generations.
-
Creation of phylogenic
trees to understand the
similarities in various
gene groups using certain
Bioinfomatics tools.
-
Data analysis of any functional
genomic experimental data.
For instance, transgenic
phenotypic data generated
by transformation experiments
in any organism can be
analyzed and a comprehensive
report be submitted for
each experiment
-
Validate data analysis
for its correctness/reproducibility
vis-à-vis published
literature, whenever available
-
Develop new data analysis,
visualization or reporting
tools depending on the
requirement
End-to-end
microarray data analysis:
We import your microarray
images for further analysis
if you are looking for end-to-end
services. Thereafter we
analyze gene expression
patterns by applying various
statistical techniques.
We provide comprehensive
expression analysis reports.
Gene
expression analysis:
We import multi-platform
image analyzed data from
various sources like Scanarray,
Genepixpro, Agilent and
Affymetrix. Further, we
provide preprocessing, image
normalization and comprehensive
statistical analysis reports.
We can also help you with
internet-based linking to
various public databases
for verification and validation.
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